Seriously, the above link is to the best song and video ever. I may be the only one who is obsessed with the (now old?) series of Roswell, but sigh.
Let's start at the beginning, shall we?
Liz and Max
Liz gets shot while working the diner, and Max, who is an alien from another planet (obviously) saves her life. How? His power is to heal. Anyway, while doing so, they get flashes of each others life, which they deem a soulmate thing. She eventually breaks up with her boyfriend, Kyle (who soon gets wrapped up into the whole alien thing) to be with Max.
Isabel, Max's sister, has the power to dream-walk (so cool!) and FINALLY falls for Alex, who is Maria and Liz's best friend. Of course, this happens before Tess (an alien introduced later on who is 'destined' to be with Max. Blah.) mind warps him so much that she kills him accidentally. Everyone is devastated, and Isabel either hallucinates seeing him quite often in her waking life until she gets married to Jesse, an unsuspecting lawyer now working at her Dad's firm.